08-P015 Human ASPM participates in cleavage furrow orientation and cytokinesis
نویسندگان
چکیده
منابع مشابه
08-P015 Human ASPM participates in cleavage furrow orientation and cytokinesis
During development of the vertebrate CNS, a precise control of planar orientation of the mitotic spindle of dividing neuroepithelial progenitors regulates the equal partitioning of apical attachment sites. This is necessary to maintain sister cells within the neuroepithelial structure. We have previously demonstrated an essential role for the G-protein regulator LGN in this process. Here we use...
متن کاملMitochondria Localize to the Cleavage Furrow in Mammalian Cytokinesis
Mitochondria are dynamic organelles with multiple cellular functions, including ATP production, calcium buffering, and lipid biosynthesis. Several studies have shown that mitochondrial positioning is regulated by the cytoskeleton during cell division in several eukaryotic systems. However, the distribution of mitochondria during mammalian cytokinesis and whether the distribution is regulated by...
متن کاملAlpha-actinin localization in the cleavage furrow during cytokinesis
We used antibodies against alpha-actinin and myosin labeled directly with contrasting fluorochromes to localize these contractile proteins simultaneously in dividing chick embryo cells. During mitosis anti-alpha-actinin stains diffusely the entire cytoplasm including the mitotic spindle, while in the same cells intense antimyosin staining delineates the spindle. During cytokinesis both antibodi...
متن کاملA Secreted Protein Promotes Cleavage Furrow Maturation during Cytokinesis
Developmental modifications in cell shape depend on dynamic interactions between the extracellular matrix and cytoskeleton. In contrast, existing models of cytokinesis describe substantial cell surface remodeling that involves many intracellular regulatory and structural proteins but includes no contribution from the extracellular matrix [1-3]. Here, we show that extracellular hemicentins assem...
متن کاملSite selection for the cleavage furrow at cytokinesis.
The question of how the site for division of the cytoplasm is determined at the end of mitosis has been studied for over a century, and it remains an active, controversial and fascinating problem in cell biology. This problem draws on the use of several model cell types, with the goal of understanding and identifying how the cell cycle regulates signals between the mitotic apparatus and the cel...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.322